Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass.

ABSTRACT: The transforming growth factor-β (TGF-β) signaling network is a critical regulator of skeletal muscle mass and function and, thus, is an attractive therapeutic target for combating muscle disease, but the underlying mechanisms of action remain undetermined. We report that follistatin-based interventions (which modulate TGF-β network activity) can promote muscle hypertrophy that ameliorates aging-associated muscle wasting. However, the muscles of old sarcopenic mice demonstrate reduced response to follistatin compared with healthy young-adult musculature. Quantitative proteomic and transcriptomic analyses of young-adult muscles identified a transcription/translation signature elicited by follistatin exposure, which included repression of ankyrin repeat and SOCS box protein 2 (Asb2).

SUBMITTER: Davey JR 

PROVIDER: S-EPMC4863241 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature