Vitamin D Receptor Polymorphism and Breast Cancer Risk: A Meta-Analysis.

ABSTRACT: The objective was to perform a meta-analysis to summarize the available evidence from prospective nested case-control studies on the association of vitamin D receptor (VDR) polymorphism and the risk of breast cancer.We searched PubMed, ISI web of science, EMBASE, and reference lists for included articles. Study specific odds ratios (ORs) and 95% confidence intervals (CIs) were pooled by using fixed-effect or random-effects models.Eight studies were included in the meta-analysis. There were no association between Fok1 gene allele contrast f versus F (OR: 0.859; 95%CI: 0.685-1.079), ff versus FF (OR: 0.893; 95%CI: 0.763-1.045), recessive models ff versus FF+Ff (OR: 0.932; 95%CI: 0.796-1.092), and dominant models ff+Ff versus FF (OR: 0.899; 95%CI: 0.780-1.037). The estimated VDR polymorphism

SUBMITTER: Lu D 

PROVIDER: S-EPMC4863774 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature