MAP3K11/GDF15 axis is a critical driver of cancer cachexia.

ABSTRACT:

Background

Cancer associated cachexia affects the majority of cancer patients during the course of the disease and thought to be directly responsible for about a quarter of all cancer deaths. Current evidence suggests that a pro-inflammatory state may be associated with this syndrome although the molecular mechanisms responsible for the development of cachexia are poorly understood. The purpose of this work was the identification of key drivers of cancer cachexia that could provide a potential point of intervention for the treatment and/or prevention of this syndrome.

Methods

Genetically engineered and xenograft tumour models were used to dissect the molecular mechanisms driving cancer cachexia. Cytokine profiling from the plasma of cachectic and non-cachectic cancer patient

SUBMITTER: Lerner L 

PROVIDER: S-EPMC4863827 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature