Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness.

ABSTRACT:

Background

The skeletal muscle system plays an important role in the independence of older adults. In this study we examine differences in the skeletal muscle transcriptome between healthy young and older subjects and (pre-)frail older adults. Additionally, we examine the effect of resistance-type exercise training on the muscle transcriptome in healthy older subjects and (pre-)frail older adults.

Methods

Baseline transcriptome profiles were measured in muscle biopsies collected from 53 young, 73 healthy older subjects, and 61 frail older subjects. Follow-up samples from these frail older subjects (31 samples) and healthy older subjects (41 samples) were collected after 6 months of progressive resistance-type exercise training. Frail older subjects trained twice per week and

SUBMITTER: Hangelbroek RW 

PROVIDER: S-EPMC4863830 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature