Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas.

ABSTRACT:

Purpose

To apply DTI to detect early extrapontine extension of pediatric diffuse intrinsic pontine glioma along the corticospinal tracts.

Methods

In children with diffuse intrinsic pontine glioma, low-grade brainstem glioma, and age-matched controls, DTI metrics were measured in the posterior limb of the internal capsule and posterior centrum semiovale. Histological examination was available in one patient.

Results

6 diffuse intrinsic pontine glioma, 8 low-grade brainstem glioma, and two groups of 25 controls were included. In diffuse intrinsic pontine glioma compared to controls, fractional anisotropy was lower in the bilateral posterior limb of the internal capsule, axial diffusivity was lower in the bilateral posterior centrum semiovale and posterior limb of the in

SUBMITTER: Wagner MW 

PROVIDER: S-EPMC4863950 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature