PyClone: statistical inference of clonal population structure in cancer.

ABSTRACT: We introduce PyClone, a statistical model for inference of clonal population structures in cancers. PyClone is a Bayesian clustering method for grouping sets of deeply sequenced somatic mutations into putative clonal clusters while estimating their cellular prevalences and accounting for allelic imbalances introduced by segmental copy-number changes and normal-cell contamination. Single-cell sequencing validation demonstrates PyClone's accuracy.

SUBMITTER: Roth A 

PROVIDER: S-EPMC4864026 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature