Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

ABSTRACT: Human cancers, including breast cancers, comprise clones differing in mutation content. Clones evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment is used as a means of capturing and studying tumour biology, and breast tumour xenografts are generally assumed to be reasonable models of the originating tumours. However, the consequences and reproducibility of engraftment and propagation on the genomic clonal architecture of tumours have not been systematically examined at single-cell resolution. Here we show, using deep-genome and single-cell sequencing methods, the clonal dynamics of initial engraftment and subsequent serial propagation of primar

SUBMITTER: Eirew P 

PROVIDER: S-EPMC4864027 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature