Epigenetic dysregulation in follicular lymphoma.

ABSTRACT: The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.

SUBMITTER: Araf S 

PROVIDER: S-EPMC4864036 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature