Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp.

ABSTRACT: Leptospirosis is a worldwide spread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. In severe infections, hemostatic impairments such as coagulation/fibrinolysis dysfunction are frequently observed. These complications often occur when the host response is controlled and/or modulated by the bacterial pathogen. In the present investigation, we aimed to analyze the modulation of the hemostatic and inflammatory host responses by the bacterial pathogen Leptospira. The effects of leptospires and their secreted products on stimulation of human intrinsic and extrinsic pathways of coagulation were investigated by means of altered clotting times, assembly and activation of contact system and induction of tissue factor. We sh

SUBMITTER: Vieira ML 

PROVIDER: S-EPMC4864083 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature