Organelle Size Scaling of the Budding Yeast Vacuole by Relative Growth and Inheritance.

ABSTRACT: It has long been noted that larger animals have larger organs compared to smaller animals of the same species, a phenomenon termed scaling [1]. Julian Huxley proposed an appealingly simple model of "relative growth"-in which an organ and the whole body grow with their own intrinsic rates [2]-that was invoked to explain scaling in organs from fiddler crab claws to human brains. Because organ size is regulated by complex, unpredictable pathways [3], it remains unclear whether scaling requires feedback mechanisms to regulate organ growth in response to organ or body size. The molecular pathways governing organelle biogenesis are simpler than organogenesis, and therefore organelle size scaling in the cell provides a more tractable case for testing Huxley's model. We ask the question: is it pos

SUBMITTER: Chan YH 

PROVIDER: S-EPMC4864093 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature