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ABSTRACT: Purpose
Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In women, higher plasma 25-hydroxyvitamin D (25(OH)D) has been shown to be associated with longer telomere length, but the relationship has not been assessed in men.Methods
We conducted a cross-sectional analysis of 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)2D) and relative leukocyte telomere length (LTL) among 2483 men [1832 men for 1,25(OH)2D] who were selected as cases and controls in three studies of telomeres and cancer nested within the Health Professionals Follow-up Study. We also genotyped 95 SNPs representing common genetic variation in vitamin D pathway genes. LTL was measured by quantitative PCR, and z-scores within each study were calculated. Associations were assessed by linear as well as logistic regression adjusting for age and other potential confounders.Results
Age (P-trend < 0.0001), pack-years of smoking (P-trend = 0.04) and body mass index (P-trend = 0.05) were inversely associated with LTL. Neither 25(OH)D nor 1,25(OH)2D was associated with LTL (multivariable-adjusted P-trend 0.69 and 0.41, respectively, for the linear regression model). One SNP in the retinoid X receptor alpha gene was associated with long LTL (P = 0.0003).Conclusions
In this cross-sectional study of men, 25(OH)D and 1,25(OH)2D were not associated with relative LTL.
SUBMITTER: Julin B
PROVIDER: S-EPMC4864153 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Julin Bettina B Shui Irene M IM Prescott Jennifer J Giovannucci Edward L EL De Vivo Immaculata I
European journal of nutrition 20151111 2
<h4>Purpose</h4>Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In women, higher plasma 25-hydroxyvitamin D (25(OH)D) has been shown to be associated with longer telomere length, but the relationship has not been assessed in men.<h4>Methods</h4>We conducted a cross-sectional analysis of 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)<sub>2</sub>D) and relative leukocyte telomere length (LTL) among 2483 men [1832 men for 1,25(OH)<sub>2</sub>D] ...[more]