Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus.

ABSTRACT: During CNS development, microglia transform from highly mobile amoeboid-like cells to primitive ramified forms and, finally, to highly branched but relatively stationary cells in maturity. The factors that control developmental changes in microglia are largely unknown. Because microglia detect and clear apoptotic cells, developmental changes in microglia may be controlled by neuronal apoptosis. Here, we assessed the extent to which microglial cell density, morphology, motility, and migration are regulated by developmental apoptosis, focusing on the first postnatal week in the mouse hippocampus when the density of apoptotic bodies peaks at postnatal day 4 and declines sharply thereafter. Analysis of microglial form and distribution in situ over the first postnatal week showed that, although

SUBMITTER: Eyo UB 

PROVIDER: S-EPMC4864211 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature