Inflammation-associated changes in lipid composition and the organization of the erythrocyte membrane.

ABSTRACT:

Background

Reduced erythrocyte survival and deformability may contribute to the so-called anemia of inflammation observed in septic patients. Erythrocyte structure and function are affected by both the membrane lipid composition and the organization. We therefore aimed to determine whether these parameters are affected during systemic inflammation.

Methods

A sensitive matrix-assisted laser desorption and ionization time-of-flight mass spectrometric method was used to investigate the effect of plasma components of 10 patients with septic shock and of 10 healthy volunteers subjected to experimental endotoxemia on erythrocyte membrane lipid composition.

Results

Incubation of erythrocytes from healthy control donors with plasma from patients with septic shock resulted in

SUBMITTER: Dinkla S 

PROVIDER: S-EPMC4864322 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature