Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis.

ABSTRACT:

Background and aims

The prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the development and progression of NAFLD to NASH and cirrhosis is poorly understood. This study aimed to quantify the bile acid metabolome in healthy subjects and patients with non-cirrhotic NASH under fasting conditions and after a standardized meal.

Methods

Liquid chromatography tandem mass spectroscopy was used to quantify 30 serum and 16 urinary bile acids from 15 healthy volunteers and 7 patients with biopsy-confirmed NASH. Bile acid concentrations were measured at two fasting and four post-prandial time points following a high-fat meal to induce gallbladder contraction and bile acid reabsorption from the

SUBMITTER: Ferslew BC 

PROVIDER: S-EPMC4864493 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature