Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.

ABSTRACT: A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

SUBMITTER: Korenchan DE 

PROVIDER: S-EPMC4864526 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature