Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists.

ABSTRACT: Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are infrequent autoimmune cholestatic liver diseases, that disproportionate to their incidence and prevalence, remain very important causes of morbidity and mortality for patients with liver disease. Mechanistic insights spanning genetic risks and biological pathways to liver injury and fibrosis have led to a renewed interest in developing therapies beyond ursodeoxycholic acid that are aimed at both slowing disease course and improving quality of life. International cohort studies have facilitated a much greater understanding of disease heterogeneity, and in so doing highlight the opportunity to provide patients with a more individualized assessment of their risk of progressive liver disease, based on clinical, labora

SUBMITTER: Trivedi PJ 

PROVIDER: S-EPMC4864755 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature