Application of linear mixed models to study genetic stability of height and body mass index across countries and time.

ABSTRACT:

Background

It is now possible to estimate genetic correlations between two independent samples when there is no overlapping phenotypic information. We applied the latest bivariate genomic methods to children in the UK and older adults in Sweden to ask two questions. Are the same variants driving individual differences in anthropometric traits in these two populations, and are these variants as important in childhood as they are later in life?

Methods

A sample of 3152 11-year-old children in the UK was compared with a sample of 6813 adults with an average age of 65 in Sweden. Genotypes were imputed from 1000 genomes with combined 9 767 136 single nucleotide polymorphisms meeting quality control criteria in both samples. Two cross-sample GCTA-GREML analyses and linkage disequi

SUBMITTER: Trzaskowski M 

PROVIDER: S-EPMC4864877 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature