The epigenetic clock and telomere length are independently associated with chronological age and mortality.

ABSTRACT:

Background

Telomere length and DNA methylation have been proposed as biological clock measures that track chronological age. Whether they change in tandem, or contribute independently to the prediction of chronological age, is not known.

Methods

We address these points using data from two Scottish cohorts: the Lothian Birth Cohorts of 1921 (LBC1921) and 1936 (LBC1936). Telomere length and epigenetic clock estimates from DNA methylation were measured in 920 LBC1936 participants (ages 70, 73 and 76 years) and in 414 LBC1921 participants (ages 79, 87 and 90 years).

Results

The epigenetic clock changed over time at roughly the same rate as chronological age in both cohorts. Telomere length decreased at 48-67 base pairs per year on average. Weak, non-significant correlatio

SUBMITTER: Marioni RE 

PROVIDER: S-EPMC4864882 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature