Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.

ABSTRACT:

Objective

Hallux valgus (HV) affects ∼36% of Caucasian adults. Although considered highly heritable, the underlying genetic determinants are unclear. We conducted the first genome-wide association study (GWAS) aimed to identify genetic variants associated with HV.

Methods

HV was assessed in three Caucasian cohorts (n=2263, n=915 and n=1231 participants, respectively). In each cohort, a GWAS was conducted using 2.5 M imputed SNPs. Mixed-effect regression with the additive genetic model adjusted for age, sex, weight and within-family correlations was used for both sex-specific and combined analyses. To combine GWAS results across cohorts, fixed-effect inverse-variance meta-analyses were used. Following meta-analyses, top-associated findings were also examined in an African Ame

SUBMITTER: Hsu YH 

PROVIDER: S-EPMC4864963 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature