Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1.

ABSTRACT: The mitochondrial cytochrome c oxidase assembles in the inner membrane from subunits of dual genetic origin. The assembly process of the enzyme is initiated by membrane insertion of the mitochondria-encoded Cox1 subunit. During complex maturation, transient assembly intermediates, consisting of structural subunits and specialized chaperone-like assembly factors, are formed. In addition, cofactors such as heme and copper have to be inserted into the nascent complex. To regulate the assembly process, the availability of Cox1 is under control of a regulatory feedback cycle in which translation of COX1 mRNA is stalled when assembly intermediates of Cox1 accumulate through inactivation of the translational activator Mss51. Here we isolate a cytochrome c oxidase assembly intermediate in preparat

SUBMITTER: Bareth B 

PROVIDER: S-EPMC4865315 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature