B0 -orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T.

ABSTRACT:

Purpose

To investigate B0 -field-orientation dependent white matter contrast in the human brainstem based on R2 * and frequency difference (Δf) mapping from gradient echo (GRE) imaging at 11.7T.

Methods

Multi-echo GRE data were acquired from two fixed human brainstem specimens at multiple orientations with respect to the static B0 field. The B0 -orientation dependent modulation curves of R2 * and Δf measurements between short and long echo time regimes were used to reconstruct maps of three-dimensional (3D) white matter orientation vectors. The results were compared with maps from diffusion MRI, susceptibility tensor imaging, and histological staining of the same specimens.

Results

R2 * and Δf maps demonstrated distinct and significant contrast modulation between the

SUBMITTER: Aggarwal M 

PROVIDER: S-EPMC4865411 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature