A homology-based pipeline for global prediction of post-translational modification sites.

ABSTRACT: The pathways of protein post-translational modifications (PTMs) have been shown to play particularly important roles for almost any biological process. Identification of PTM substrates along with information on the exact sites is fundamental for fully understanding or controlling biological processes. Alternative computational strategies would help to annotate PTMs in a high-throughput manner. Traditional algorithms are suited for identifying the common organisms and tissues that have a complete PTM atlas or extensive experimental data. While annotation of rare PTMs in most organisms is a clear challenge. In this work, to this end we have developed a novel homology-based pipeline named PTMProber that allows identification of potential modification sites for most of the proteomes lacking PT

SUBMITTER: Chen X 

PROVIDER: S-EPMC4865729 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature