Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer.

ABSTRACT:

Background

Expression of the chemokine CXCL14 has previously been shown to be elevated in the tumour stroma of, for example, prostate and breast cancer. Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied.

Methods

CXCL14 mRNA expression was analysed in a breast cancer tissue microarray (TMA) of formalin-fixed, paraffin-embedded tumours by the RNAscope 2.0 Assay. Epithelial and stromal expression was analysed separately and correlated with clinicopathological characteristics and survival.

Results

CXCL14 was variably and independently expressed in malignant and stromal cells of breast cancer. Total and strom

SUBMITTER: Sjoberg E 

PROVIDER: S-EPMC4865967 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature