Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.

ABSTRACT:

Background

Numerous germline single-nucleotide polymorphisms increase susceptibility to prostate cancer, some lying near genes involved in cellular radiation response. This study investigated whether prostate cancer patients with a high genetic risk have increased toxicity following radiotherapy.

Methods

The study included 1560 prostate cancer patients from four radiotherapy cohorts: RAPPER (n=533), RADIOGEN (n=597), GenePARE (n=290) and CCI (n=150). Data from genome-wide association studies were imputed with the 1000 Genomes reference panel. Individuals were genetically similar with a European ancestry based on principal component analysis. Genetic risks were quantified using polygenic risk scores. Regression models tested associations between risk scores and 2-year toxicit

SUBMITTER: Ahmed M 

PROVIDER: S-EPMC4865979 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature