Induction of the type I interferon response in neurological forms of Gaucher disease.

ABSTRACT:

Background

Neuroinflammation is a key phenomenon in the pathogenesis of many neurodegenerative diseases. Understanding the mechanisms by which brain inflammation is engaged and delineating the key players in the immune response and their contribution to brain pathology is of great importance for the identification of novel therapeutic targets for these devastating diseases. Gaucher disease, the most common lysosomal storage disease, is caused by mutations in the GBA1 gene and is a significant risk factor for Parkinson's disease; in some forms of Gaucher disease, neuroinflammation is observed.

Methods

An unbiased gene profile analysis was performed on a severely affected brain area of a neurological form of a Gaucher disease mouse at a pre-symptomatic stage; the mouse used fo

SUBMITTER: Vitner EB 

PROVIDER: S-EPMC4866012 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature