Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet.

ABSTRACT:

Background

Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the therapeutic ketogenic diet (KD) prolongs survival in mouse models of glioma, explained by both direct tumor growth inhibition and suppression of pro-inflammatory microenvironment conditions. The aim of this study is to assess the effects of the KD on the glioma reactive immune response.

Methods

The GL261-Luc2 intracranial mouse model of glioma was used to investigate the effects of the KD on the tumor-specific immune response. Tumor-infiltrating CD8+ T cells, CD4+ T cells and natural killer (NK) cells were analyzed by flow cytometry. The expression of immune

SUBMITTER: Lussier DM 

PROVIDER: S-EPMC4866042 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature