Insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling.

ABSTRACT:

Background

The respiratory tract of swine is colonized by several bacteria among which are three Mycoplasma species: Mycoplasma flocculare, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. While colonization by M. flocculare is virtually asymptomatic, M. hyopneumoniae is the causative agent of enzootic pneumonia and M. hyorhinis is present in cases of pneumonia, polyserositis and arthritis. The genomic resemblance among these three Mycoplasma species combined with their different levels of pathogenicity is an indication that they have unknown mechanisms of virulence and differential expression, as for most mycoplasmas.

Methods

In this work, we performed whole-genome metabolic network reconstructions for these three mycoplasmas. Cultivation tests and metabolomic experiments

SUBMITTER: Ferrarini MG 

PROVIDER: S-EPMC4866288 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature