Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development.

ABSTRACT:

Background

During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression profiles throughout development are determined by an underlying network of precise regulatory interactions between individual genes. Elucidating the organizing principles that shape this gene regulatory network is one of the central goals of developmental biology. Whether the developmental programme is the result of a dynamic driven by a fixed architecture of regulatory interactions, or alternatively, the result of waves of regulatory reorganization is not known.

Results

Here we contrast these two alternative models by examining existing expression data

SUBMITTER: Monzon-Sandoval J 

PROVIDER: S-EPMC4866393 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature