Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia.

ABSTRACT:

Background

In schizophrenia, genetic background may provide a substrate for intrinsic maldevelopment of the brain through environmental influences, by recruiting neurotrophic factors and cytokines, to trigger the changes that lead to impaired neuronal functions. Cytokines being the key regulators of immune/inflammatory reactions are also known to influence the dopaminergic, noradrenergic, and serotonergic neurotransmission. Therefore, functional polymorphisms in cytokine genes may result in imbalances in the pro- and anti-inflammatory cytokine production.

Methods

We screened polymorphisms in pro- and anti-inflammatory cytokine genes using a case-control association study in a South Indian population. The role of allele, genotype, haplotype, and diplotypes of these cytokine g

SUBMITTER: Srinivas L 

PROVIDER: S-EPMC4866417 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature