Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

ABSTRACT: The ability to withstand low oxygen (hypoxia tolerance) is a polygenic and mechanistically conserved trait that has important implications for both human health and evolution. However, little is known about the diversity of genetic mechanisms involved in hypoxia adaptation in evolving populations. We used experimental evolution and whole-genome sequencing in Drosophila melanogaster to investigate the role of natural variation in adaptation to hypoxia. Using a generalized linear mixed model we identified significant allele frequency differences between three independently evolved hypoxia-tolerant populations and normoxic control populations for approximately 3,800 single nucleotide polymorphisms. Around 50% of these variants are clustered in 66 distinct genomic regions. These regions contai

SUBMITTER: Jha AR 

PROVIDER: S-EPMC4866538 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature