Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life.

ABSTRACT: To maintain a symbiotic relationship between the host and its resident intestinal microbiota, appropriate mucosal T cell responses to commensal antigens must be established. Mice acquire both IgG and IgA maternally; the former has primarily been implicated in passive immunity to pathogens while the latter mediates host-commensal mutualism. Here, we report the surprising observation that mice generate T cell-independent and largely Toll-like receptor (TLR)-dependent IgG2b and IgG3 antibody responses against their gut microbiota. We demonstrate that maternal acquisition of these antibodies dampens mucosal T follicular helper responses and subsequent germinal center B cell responses following birth. This work reveals a feedback loop whereby T cell-independent, TLR-dependent antibodies limit m

SUBMITTER: Koch MA 

PROVIDER: S-EPMC4866587 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature