Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency.

ABSTRACT:

Background

Common variable immunodeficiency (CVID) is an antibody deficiency treated with immunoglobulin; however, patients can have noninfectious inflammatory conditions that lead to heightened morbidity and mortality.

Objectives

Modular analyses of RNA transcripts in whole blood previously identified an upregulation of many interferon-responsive genes. In this study we sought the cell populations leading to this signature.

Methods

Lymphoid cells were measured in peripheral blood of 55 patients with CVID (31 with and 24 without inflammatory/autoimmune complications) by using mass cytometry and flow cytometry. Surface markers, cytokines, and transcriptional characteristics of sorted innate lymphoid cells (ILCs) were defined by using quantitative PCR. Gastrointestinal

SUBMITTER: Cols M 

PROVIDER: S-EPMC4866594 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature