Fractal Dimension Analysis of Subcortical Gray Matter Structures in Schizophrenia.

ABSTRACT: A failure of adaptive inference-misinterpreting available sensory information for appropriate perception and action-is at the heart of clinical manifestations of schizophrenia, implicating key subcortical structures in the brain including the hippocampus. We used high-resolution, three-dimensional (3D) fractal geometry analysis to study subtle and potentially biologically relevant structural alterations (in the geometry of protrusions, gyri and indentations, sulci) in subcortical gray matter (GM) in patients with schizophrenia relative to healthy individuals. In particular, we focus on utilizing Fractal Dimension (FD), a compact shape descriptor that can be computed using inputs with irregular (i.e., not necessarily smooth) surfaces in order to quantify complexity (of geometrical propertie

SUBMITTER: Zhao G 

PROVIDER: S-EPMC4866699 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature