Hepatic autophagy contributes to the metabolic response to dietary protein restriction.

ABSTRACT: Autophagy is an essential cellular response which acts to release stored cellular substrates during nutrient restriction, and particularly plays a key role in the cellular response to amino acid restriction. However, there has been limited work testing whether the induction of autophagy is required for adaptive metabolic responses to dietary protein restriction in the whole animal. Here, we found that moderate dietary protein restriction led to a series of metabolic changes in rats, including increases in food intake and energy expenditure, the downregulation of hepatic fatty acid synthesis gene expression and reduced markers of hepatic mitochondrial number. Importantly, these effects were also associated with an induction of hepatic autophagy. To determine if the induction of autophagy co

SUBMITTER: Henagan TM 

PROVIDER: S-EPMC4867053 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature