Interictal high-frequency oscillations generated by seizure onset and eloquent areas may be differentially coupled with different slow waves.

ABSTRACT:

Objective

High-frequency oscillations (HFOs) can be spontaneously generated by seizure-onset and functionally-important areas. We determined if consideration of the spectral frequency bands of coupled slow-waves could distinguish between epileptogenic and physiological HFOs.

Methods

We studied a consecutive series of 13 children with focal epilepsy who underwent extraoperative electrocorticography. We measured the occurrence rate of HFOs during slow-wave sleep at each electrode site. We subsequently determined the performance of HFO rate for localization of seizure-onset sites and undesirable detection of nonepileptic sensorimotor-visual sites defined by neurostimulation. We likewise determined the predictive performance of modulation index: MI(XHz)&(YHz), reflecting the str

SUBMITTER: Nonoda Y 

PROVIDER: S-EPMC4867192 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature