MicroRNA polymorphisms and risk of colorectal cancer.

ABSTRACT:

Background

miRNAs act as post-transcriptional regulators of gene expression. Genetic variation in miRNA-encoding sequences or their corresponding binding sites may affect the fidelity of the miRNA-mRNA interaction and subsequently alter the risk of cancer development.

Methods

This study expanded the search for miRNA-related polymorphisms contributing to the etiology of colorectal cancer across the genome using a novel platform, the Axiom miRNA Target Site Genotyping Array (237,858 markers). After quality control, the study included 596 cases and 429 controls from the Molecular Epidemiology of Colorectal Cancer study, a population-based case-control study of colorectal cancer in northern Israel. The association between each marker and colorectal cancer status was examined ass

SUBMITTER: Schmit SL 

PROVIDER: S-EPMC4867219 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature