Low functional robustness in mesial temporal lobe epilepsy.

ABSTRACT:

Objectives

Brain functional topology was investigated in patients with mesial temporal lobe epilepsy (mTLE) by means of graph theory measures in two differentially defined graphs. Measures of segregation, integration, and centrality were compared between subjects with mTLE and healthy controls (HC).

Methods

Eleven subjects with mTLE (age 36.5±10.9years) and 15 age-matched HC (age 36.8±14.0years) participated in this study. Both anatomically and functionally defined adjacency matrices were used to investigate the measures. Binary undirected graphs were constructed to study network segregation by calculating global clustering and modularity, and network integration by calculating local and global efficiency. Node degree and participation coefficient were also computed in order

SUBMITTER: Garcia-Ramos C 

PROVIDER: S-EPMC4867275 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature