Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease.

ABSTRACT:

Background and purpose

In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported, especially in the striatum. Quantitative susceptibility mapping by using MR phase imaging allows in vivo measurements of tissue magnetic susceptibility, which has been shown to correlate well with iron levels in brain gray matter and is believed to be more specific than other imaging-based iron measures. The purpose of this study was to investigate the use of magnetic susceptibility as a biomarker of disease progression.

Materials and methods

Fifteen subjects with premanifest Huntington disease and 16 age-matched healthy controls were scanned at 7T. Magnetic susceptibility, effective relaxation,

SUBMITTER: van Bergen JM 

PROVIDER: S-EPMC4867278 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature