Development and validation of a measure of informed choice for women undergoing non-invasive prenatal testing for aneuploidy.

ABSTRACT: Non-invasive prenatal testing (NIPT) using cell-free DNA for aneuploidy is a highly accurate screening test; however, concerns exist around the potential for routinisation of testing. The multidimensional measure of informed choice (MMIC) is a quantitative instrument developed to assess informed choice for Down syndrome screening (DSS). We have validated a modified MMIC for NIPT and measured informed choice among women offered NIPT in a public health service. The measure was distributed to women recruited across eight maternity units in the United Kingdom who had accepted DSS. Construct validity was assessed by simultaneously conducting qualitative interviews. Five hundred and eighty-five questionnaires were completed and 45 interviews conducted after blood-draw (or equivalent for those th

SUBMITTER: Lewis C 

PROVIDER: S-EPMC4867447 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature