Sepsis in preterm infants causes alterations in mucosal gene expression and microbiota profiles compared to non-septic twins.

ABSTRACT: Sepsis is a life-threatening condition in preterm infants. Neonatal microbiota plays a pivotal role in the immune system maturation. Changes in gut microbiota have been associated to inflammatory disorders; however, a link with sepsis in the neonatal period has not yet been established. We aimed to analyze gut microbiota and mucosal gene expression using non-invasively obtained samples to provide with an integrative perspective of host-microbe interactions in neonatal sepsis. For this purpose, a prospective observational case-control study was conducted in septic preterm dizygotic twins and their non-septic twin controls. Fecal samples were used for both microbiota analysis and host genome-wide expression using exfoliated intestinal cells. Gene expression of exfoliated intestinal cells in

SUBMITTER: Cernada M 

PROVIDER: S-EPMC4867619 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature