Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.

ABSTRACT:

Background and purpose

Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present in adipocytes and the stromal vascular fraction of human adipose tissue (AT), is up-regulated in AT of insulin-resistant morbidly obese subjects compared with healthy lean subjects. The aim of this study was to explore the effects of in vitro and in vivo administration of GLP-1 and its analogues on AT and adipocyte functions from T2D morbidly obese subjects.

Experimental approach

We analysed the effects of GLP-1 on human AT and isolated adipocytes in vitro and the effects of GLP-1 mimetics on AT of morbidly obese T2D

SUBMITTER: El Bekay R 

PROVIDER: S-EPMC4867741 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature