Expression of IFITM1 as a prognostic biomarker in resected gastric and esophageal adenocarcinoma.

ABSTRACT:

Background

There is an increasing amount of reports on IFITM1 (interferon-inducible transmembrane protein 1) in various malignancies. The aim of this study was to examine the expression of IFITM1 and its prognostic significance in gastroesophageal adenocarcinoma.

Methods

Tissue samples were obtained from a consecutive cohort of 174 patients surgically treated between 2006 and 2010 for gastroesophageal (gastric, gastroesophageal junction and esophageal) adenocarcinoma, not subjected to neoadjuvant therapy. Expression of IFITM1 was examined using immunohistochemistry on tissue microarrays of primary tumors and paired samples of adjacent normal epithelium, intestinal metaplasia and lymph node metastases.

Results

Expression of IFITM1 was significantly elevated in primary

SUBMITTER: Borg D 

PROVIDER: S-EPMC4867989 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature