Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.

ABSTRACT:

Background

BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1. The E3 ubiquitin ligase HERC2 facilitates the assembly of the RNF8-UBC13 complex to recruit BRCA1 to DNA damage sites. The combined analysis of multiple components of the pathway leading to the recruitment of BRCA1 at DNA damage sites has the potentiality to improve the BRCA1 predictive model.

Methods

We retrospectively analyzed 71 paraffin-embedded tumor samples from advanced non-small-cell lung cancer patients treated with first-line platinum based chemotherapy and measured the mRNA expression levels of BRCA1, RNF8, UBC13 and HERC2 usin

SUBMITTER: Bonanno L 

PROVIDER: S-EPMC4868003 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature