A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis.

ABSTRACT:

Background

Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. Multiple factors exist that safeguard these genes against dysregulated expression. The list of identified negative regulators that play such a role in Drosophila development continues to expand.

Results

By using RNAi transgene-induced gene silencing coupled to spatio/temporal assessment, we have unraveled an important role for the Drosophila dopamine 1-like receptor, Dop1R2, in development. We show that Dop1R2 knockdown leads to pre-adult lethality. In adults that escape death, abnormal wing expansion and/or me

SUBMITTER: Regna K 

PROVIDER: S-EPMC4868058 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature