Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.

ABSTRACT:

Purpose

This study aims to identify which aspects of the pupil light reflex are most influenced by rods and cones independently by analyzing pupil recordings from different mouse models of photoreceptor deficiency.

Methods

One-month-old wild type (WT), rodless (Rho-/-), coneless (Cnga3-/-), or photoreceptor less (Cnga3-/-; Rho-/- or Gnat1-/-) mice were subjected to brief red and blue light stimuli of increasing intensity. To describe the initial dynamic response to light, the maximal pupillary constriction amplitudes and the derivative curve of the first 3 seconds were determined. To estimate the postillumination phase, the constriction amplitude at 9.5 seconds after light termination was related to the maximal constriction amplitude.

Results

Rho-/- mice showed decrea

SUBMITTER: Kostic C 

PROVIDER: S-EPMC4868103 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature