Comprehensive craniospinal radiation for controlling central nervous system leukemia.

ABSTRACT:

Purpose

To determine the benefit of radiation therapy (RT) in resolution of neurologic symptoms and deficits and whether the type of RT fields influences central nervous system (CNS) control in adults with CNS leukemia.

Methods and materials

A total of 163 adults from 1996 to 2012 were retrospectively analyzed. Potential associations between use of radiation and outcome were investigated by univariate and multivariate analysis.

Results

The median survival time was 3.8 months after RT. Common presenting symptoms were headache in 79 patients (49%), cranial nerve VII deficit in 46 (28%), and cranial nerve II deficit in 44 (27%). RT was delivered to the base of skull in 48 patients (29%), to the whole brain (WB) in 67 (41%), and to the craniospinal axis (CS) in 48 (29%).

SUBMITTER: Walker GV 

PROVIDER: S-EPMC4868499 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature