Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes.

ABSTRACT: The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that result in the activation or repression of gene expression. Several epigenetic pathways have been shown to be highly deregulated in cancer cells. Targeting specific histone modifications represents a viable strategy to prevent oncogenic transformation, tumor growth or metastasis. Methylation of histone H3 lysine 4 has been extensively studied and shown to mark genes for expression; however this residue can also be acetylated and the specific function of this alteration is less well known. To define the relative roles of histone H3 methylation (H3K4me3) and acetylation (H3K4ac) i

SUBMITTER: Messier TL 

PROVIDER: S-EPMC4868673 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature