Characterization of the novel tumor-suppressor gene CCDC67 in papillary thyroid carcinoma.

ABSTRACT:

Background

Some studies showed an association of coiled-coil domain-containing (CCDC) genes with cancers. Our previous limited data specifically suggested a possible pathogenic role of CCDC67 in papillary thyroid cancer (PTC), but this has not been firmly established. The present study was to further investigate and establish this role of CCDC67 in PTC.

Results

The expression of CCDC67, both at mRNA and protein levels, was sharply down-regulated in PTC compared with normal thyroid tissues. Lower CCDC67 expression was significantly associated with aggressive tumor behaviors, such as advanced tumor stages and lymph node metastasis, as well as BRAF mutation. Introduced expression of CCDC67 in TPC-1 cells robustly inhibited cell proliferation, colony formation and migration, ind

SUBMITTER: Yin DT 

PROVIDER: S-EPMC4868724 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature