Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.

ABSTRACT: Cognitive function depends on transcription; however, there is little information linking altered gene expression to impaired prefrontal cortex function during aging. Young and aged F344 rats were characterized on attentional set shift and spatial memory tasks. Transcriptional differences associated with age and cognition were examined using RNA sequencing to construct transcriptomic profiles for the medial prefrontal cortex (mPFC), white matter, and region CA1 of the hippocampus. The results indicate regional differences in vulnerability to aging. Age-related gene expression in the mPFC was similar to, though less robust than, changes in the dorsolateral PFC of aging humans suggesting that aging processes may be similar. Importantly, the pattern of transcription associated with aging did

SUBMITTER: Ianov L 

PROVIDER: S-EPMC4868850 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature