BDNF Genotype Interacts with Motor Function to Influence Rehabilitation Responsiveness Poststroke.

ABSTRACT:

Background

Persistent motor impairment is common but highly heterogeneous poststroke. Genetic polymorphisms, including those identified on the brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes, may contribute to this variability by limiting the capacity for use-dependent neuroplasticity, and hence rehabilitation responsiveness.

Objective

To determine whether BDNF and APOE genotypes influence motor improvement facilitated by poststroke upper-limb rehabilitation.

Methods

BDNF-Val66Met and APOE isoform genotypes were determined using leukocyte DNA for 55 community-dwelling patients 2-123 months poststroke. All patients completed a dose-matched upper-limb rehabilitation program of either Wii-based Movement Therapy or Constraint-induced Movement Th

SUBMITTER: Shiner CT 

PROVIDER: S-EPMC4868962 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature